Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis-Reference-Cited by-同舟云学术

Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis

Published:2020-09-02 Issue:559 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Eldridge Suzanne E.¹^ORCID,Barawi Aida¹^ORCID,Wang Hui²,Roelofs Anke J.²,Kaneva Magdalena¹^ORCID,Guan Zeyu¹^ORCID,Lydon Helen³^ORCID,Thomas Bethan L.⁴,Thorup Anne-Sophie¹^ORCID,Fernandez Beatriz F.¹^ORCID,Caxaria Sara¹^ORCID,Strachan Danielle¹^ORCID,Ali Ahmed¹^ORCID,Shanmuganathan Kanatheepan¹^ORCID,Pitzalis Costantino¹^ORCID,Whiteford James R.⁵^ORCID,Henson Frances⁶^ORCID,McCaskie Andrew W.³^ORCID,De Bari Cosimo²,Dell’Accio Francesco¹^ORCID

Affiliation:

1. Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

2. Arthritis and Regenerative Medicine Laboratory, Aberdeen Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen AB25 2ZD, UK.

3. Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK.

4. Centre for Biochemical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

5. Comparative Musculoskeletal Biology Group, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.

6. Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

Abstract

Agrin heals joint surfaces by recruiting joint stem cells and inducing the formation of cartilage and bone with correct architecture in mice and sheep.

Funder

Medical Research Council

Rosetrees Trust

Versus Arthritis

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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