Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site

Author:

Bryden Steven R.12ORCID,Pingen Marieke12ORCID,Lefteri Daniella A.1ORCID,Miltenburg Janne1ORCID,Delang Leen3ORCID,Jacobs Sofie3ORCID,Abdelnabi Rana3ORCID,Neyts Johan3ORCID,Pondeville Emilie4ORCID,Major Jack12ORCID,Müller Marietta5ORCID,Khalid Henna5ORCID,Tuplin Andrew5ORCID,Varjak Margus2ORCID,Merits Andres6,Edgar Julia2ORCID,Graham Gerard J.2,Shams Kave7,McKimmie Clive S.1ORCID

Affiliation:

1. Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK.

2. Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.

3. KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium.

4. MRC‑University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.

5. School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

6. Institute of Technology, University of Tartu, 50411 Tartu, Estonia.

7. Inflammatory Skin Disease Group, Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK.

Abstract

Activation of innate immune responses to arbovirus at the mosquito bite prevents efficient systemic dissemination of virus.

Funder

Wellcome Trust

Medical Research Council

Flanders FWO

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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