Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans

Author:

Chung Liam12ORCID,Maestas David R.2ORCID,Lebid Andriana1,Mageau Ashlie2,Rosson Gedge D.3,Wu Xinqun1ORCID,Wolf Matthew T.12ORCID,Tam Ada J.1,Vanderzee Isabel2ORCID,Wang Xiaokun2ORCID,Andorko James I.12ORCID,Zhang Hong2,Narain Radhika2,Sadtler Kaitlyn4ORCID,Fan Hongni1ORCID,Čiháková Daniela5ORCID,Le Saux Claude Jourdan6,Housseau Franck1ORCID,Pardoll Drew M.1ORCID,Elisseeff Jennifer H.12ORCID

Affiliation:

1. Bloomberg~Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

2. Translational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.

3. Division of Plastic Surgery, Department of Surgery, Johns Hopkins University, Baltimore, MD, USA.

4. Section on Immuno-Engineering, National Institute for Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

5. Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

6. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Interleukin 17 and senescent cells regulate fibrosis in the foreign body response to synthetic material implants.

Funder

U.S. Department of Defense

Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

Morton Goldberg Professor of Ophthalmology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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