Spontaneous reversal of stenosis in tissue-engineered vascular grafts

Author:

Drews Joseph D.12ORCID,Pepper Victoria K.1ORCID,Best Cameron A.13ORCID,Szafron Jason M.4ORCID,Cheatham John P.5ORCID,Yates Andrew R.56ORCID,Hor Kan N.56,Zbinden Jacob C.17,Chang Yu-Chun13,Mirhaidari Gabriel J. M.13ORCID,Ramachandra Abhay B.4,Miyamoto Shinka1,Blum Kevin M.17ORCID,Onwuka Ekene A.12,Zakko Jason12ORCID,Kelly John15ORCID,Cheatham Sharon L.5ORCID,King Nakesha12,Reinhardt James W.1ORCID,Sugiura Tadahisa1,Miyachi Hideki1,Matsuzaki Yuichi1,Breuer Julie1ORCID,Heuer Eric D.1ORCID,West T. Aaron1,Shoji Toshihiro1,Berman Darren5,Boe Brian A.5ORCID,Asnes Jeremy8ORCID,Galantowicz Mark59,Matsumura Goki10ORCID,Hibino Narutoshi11ORCID,Marsden Alison L.12,Pober Jordan S.13ORCID,Humphrey Jay D.4ORCID,Shinoka Toshiharu159,Breuer Christopher K.1214ORCID

Affiliation:

1. Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205, USA.

2. Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

3. Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, OH 43210, USA.

4. Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

5. The Heart Center, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

6. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.

7. Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

8. Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA.

9. Department of Cardiothoracic Surgery, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

10. Department of Cardiovascular Surgery, Tokyo Women’s Medical University, Tokyo, Japan.

11. Department of Surgery, University of Chicago/Advocate Children’s Hospital, Chicago, IL 60453, USA.

12. Departments of Pediatrics and Bioengineering, Stanford University, Stanford, CA 94304, USA.

13. Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

14. Department of Surgery, Nationwide Children’s Hospital, Columbus, OH 43205, USA.

Abstract

Computational modeling and ovine data reveal spontaneous reversal of early tissue-engineered vascular graft stenosis, with clinical implications.

Funder

National Science Foundation

National Institutes of Health

U.S. Department of Defense

American Heart Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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