A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

Author:

Hobson-Peters Jody1ORCID,Harrison Jessica J.1ORCID,Watterson Daniel1ORCID,Hazlewood Jessamine E.2ORCID,Vet Laura J.1ORCID,Newton Natalee D.1ORCID,Warrilow David3ORCID,Colmant Agathe M. G.1ORCID,Taylor Carmel3,Huang Bixing3ORCID,Piyasena Thisun B. H.1ORCID,Chow Weng Kong4ORCID,Setoh Yin Xiang1ORCID,Tang Bing2ORCID,Nakayama Eri5ORCID,Yan Kexin2ORCID,Amarilla Alberto A.1ORCID,Wheatley Sarah3,Moore Peter R.3,Finger Mitchell3ORCID,Kurucz Nina6,Modhiran Naphak1ORCID,Young Paul R.1,Khromykh Alexander A.1,Bielefeldt-Ohmann Helle17,Suhrbier Andreas12,Hall Roy A.1ORCID

Affiliation:

1. Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.

2. Inflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.

3. Public Health Virology Laboratory, Department of Health, Queensland Government, PO Box 594, Archerfield, Queensland, Australia.

4. Australian Defence Force Malaria and Infectious Disease Institute, Gallipoli Barracks, Queensland, Australia.

5. Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.

6. Centre for Disease Control, Health Protection Division, Northern Territory Department of Health, Darwin, Northern Territory, Australia.

7. School of Veterinary Science, University of Queensland Gatton Campus, Queensland 4343, Australia.

Abstract

Insect-specific Binjari virus facilitates the production of chimeric virus particles of flavivirus pathogens for diagnostics and vaccines.

Funder

Australian Research Council

National Health and Medical Research Council

The University of Queensland

Queensland Health Support Forensic and Scientific Services

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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