Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα 13 in liver exacerbates systemic insulin resistance in mice-Reference-Cited by-同舟云学术

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα 13 in liver exacerbates systemic insulin resistance in mice

Published:2019-10-09 Issue:513 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kim Tae Hyun¹^ORCID,Koo Ja Hyun¹^ORCID,Heo Mi Jeong¹^ORCID,Han Chang Yeob¹,Kim Yong-In²,Park Shi-Young³^ORCID,Cho Il Je⁴^ORCID,Lee Chang Ho⁵,Choi Cheol Soo³⁶,Lee Jung Weon¹⁷^ORCID,Kim Won⁸^ORCID,Cho Je-Yoel²^ORCID,Kim Sang Geon¹^ORCID

Affiliation:

1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.

2. Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 08826, Korea.

3. Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine, Incheon 21999, Korea.

4. College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Korea.

5. Department of Pharmacology, Institute of Biomedical Science, College of Medicine, Hanyang University, Seoul, Korea.

6. Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Incheon 21565, Korea.

7. Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Korea.

8. Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.

Abstract

Loss of Gα 13 boosts production of liver ITIH1, resulting in systemic insulin resistance in mice that is reversed by ITIH1 neutralization by antibody.

Funder

Korea Health Industry Development Institute

Korea Institute of Oriental Medicine

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

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2. Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease

3. Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes