Ethical challenges for pediatric liver organoid transplantation-Reference-Cited by-同舟云学术

Ethical challenges for pediatric liver organoid transplantation

Published:2020-07-15 Issue:552 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Schneemann Sarah A.¹²^ORCID,Boers Sarah N.¹,van Delden Johannes J. M.¹^ORCID,Nieuwenhuis Edward E. S.²³,Fuchs Sabine A.⁴^ORCID,Bredenoord Annelien L.¹^ORCID

Affiliation:

1. Julius Center for Health Sciences and Primary Care, Department of Medical Humanities, University Medical Center Utrecht, 3508 GA, Utrecht, Netherlands.

2. Department of Pediatrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 3508 AB, Utrecht, Netherlands.

3. Science Department, University College Roosevelt, Middelburg, Netherlands.

4. Department of Metabolic Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, 3508 AB, Utrecht, Netherlands.

Abstract

The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.

Funder

ZonMw The Netherlands Organisation for Health Research and Development Health Institute

Metakids Funding

Leading Ladies Fund from the Wilhelmina Children’s Hospital

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference9 articles.

1. Organogenesis in a dish: Modeling development and disease using organoid technologies

2. Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

3. Present status and perspectives of cell-based therapies for liver diseases

4. Council for International Organizations of Medical Sciences International Ethical Guidelines for Biomedical Research Involving Human Subjects (2016).

5. World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. 64th WMA General Assembly Fortaleza Brazil (2013).

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