Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis-Reference-Cited by-同舟云学术

Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis

Published:2021-02-10 Issue:580 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Carlson Elijah L.¹^ORCID,Karuppagounder Vengadeshprabhu¹,Pinamont William J.¹^ORCID,Yoshioka Natalie K.¹^ORCID,Ahmad Adeel¹^ORCID,Schott Eric M.²^ORCID,Le Bleu Heather K.³^ORCID,Zuscik Michael J.⁴^ORCID,Elbarbary Reyad A.¹⁵,Kamal Fadia¹⁶^ORCID

Affiliation:

1. Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA.

2. Solarea Bio Inc., Cambridge, MA 02142, USA.

3. Department of Biology, University of Oregon, Eugene, OR 97403, USA.

4. Colorado Program for Skeletal Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

5. Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA.

6. Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA.

Abstract

G protein–coupled receptor kinase 2 is increased in OA, and inhibition by the antidepressant paroxetine prevents disease progression.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Arthritis National Research Foundation

National Center for Advancing Translational Sciences

The Barsumian Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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