Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

Author:

Strobl Johanna1ORCID,Pandey Ram Vinay1,Krausgruber Thomas2ORCID,Bayer Nadine1,Kleissl Lisa13ORCID,Reininger Bärbel1ORCID,Vieyra-Garcia Pablo4ORCID,Wolf Peter4ORCID,Jentus Maaia-Margo1ORCID,Mitterbauer Margit5,Wohlfarth Philipp5ORCID,Rabitsch Werner5,Stingl Georg1ORCID,Bock Christoph236ORCID,Stary Georg123ORCID

Affiliation:

1. Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.

2. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.

3. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria.

4. Department of Dermatology and Venereology, Medical University of Graz, 8036 Graz, Austria.

5. Department of Internal Medicine I, Hematopoietic Stem Cell Transplantation Unit, Medical University of Vienna, 1090 Vienna, Austria.

6. Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.

Abstract

GVHD includes an autoinflammatory host-versus-graft component from recipient-derived skin-resident memory T cells.

Funder

Austrian Academy of Sciences

Austrian Science Fund

Vienna Science and Technology Fund

Oesterreichische Nationalbank

German Foundation of Dermatology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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