Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

Author:

Claff Tobias12ORCID,Yu Jing1345ORCID,Blais Véronique6,Patel Nilkanth7ORCID,Martin Charlotte8ORCID,Wu Lijie1ORCID,Han Gye Won7ORCID,Holleran Brian J.6,Van der Poorten Olivier8,White Kate L.7ORCID,Hanson Michael A.9ORCID,Sarret Philippe6ORCID,Gendron Louis6ORCID,Cherezov Vadim7ORCID,Katritch Vsevolod7ORCID,Ballet Steven8ORCID,Liu Zhi-Jie13,Müller Christa E.2ORCID,Stevens Raymond C.17ORCID

Affiliation:

1. iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Rd, Pudong, Shanghai 201210, China.

2. PharmaCenter Bonn, University of Bonn, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany.

3. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

4. CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

5. University of the Chinese Academy of Sciences, Beijing 100049, China.

6. Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du CHUS, Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada.

7. Departments of Biological Sciences and Chemistry, Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.

8. Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.

9. GPCR Consortium, San Marcos, CA 92078, USA.

Abstract

Crystal structures provide first atomic-level insights into δ-opioid receptor activation by two structurally diverse agonists.

Funder

National Institutes of Health

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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