Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7-Reference-Cited by-同舟云学术

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

Published:2019-07-05 Issue:7 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

McComb Scott¹^ORCID,Chan Pik Ki¹^ORCID,Guinot Anna¹^ORCID,Hartmannsdottir Holmfridur¹^ORCID,Jenni Silvia¹,Dobay Maria Pamela¹²,Bourquin Jean-Pierre¹,Bornhauser Beat C.¹^ORCID

Affiliation:

1. Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.

2. IQVIA Technology and Services AG Theaterstrasse 4, 4051 Basel, Switzerland.

Abstract

Caspase-3 and -7 are redundantly required to amplify the extrinsic and intrinsic apoptotic cascade in human leukemia.

Funder

Institute for Empirical Research in Economics, University of Zurich

Swiss Cancer League

Stiftung Kinderkrebsforschung Schweiz

MAM-Fonds of the Children’s Research Centre of the University Children’s Hospital Zurich

Fondation Panacée

Novartis Foundation for biomedical research

Empiris foundation,

Swiss national Science Foundation SNF

Canadian institutes for health research CIHR

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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