The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome-Reference-Cited by-同舟云学术

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The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome

Published:2020-12-18 Issue:51 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bronisz A.¹²^ORCID,Rooj A. K.¹^ORCID,Krawczyński K.²^ORCID,Peruzzi P.¹^ORCID,Salińska E.²,Nakano I.³,Purow B.⁴,Chiocca E. A.¹,Godlewski J.¹²^ORCID

Affiliation:

1. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

2. Department of Neurochemistry, Mossakowski Medical Research Centre of Polish Academy of Sciences, Warsaw, Poland.

3. Department of Neurosurgery, University of Alabama, Birmingham, AL, USA.

4. Department of Neurology, University of Virginia, Charlottesville, VA, USA.

Abstract

A novel circRNA withholds the microRNA assembly line by arresting the manufacturing foreman in the nucleus of a cancer cell.

Funder

National Cancer Institute

National Science Center Poland

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference52 articles.

1. An estimate of the total number of true human miRNAs

2. Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

3. Prediction of Mammalian MicroRNA Targets

4. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

5. MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

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