Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity

Author:

Zhang Chi12ORCID,Li Weiyun23,Lei Xiaobo4,Xie Zhenfei2ORCID,Qi Linlin5ORCID,Wang Hui6,Xiao Xia4,Xiao Jun2ORCID,Zheng Yuxiao2ORCID,Dong Chen2,Zheng Xin2,Chen Shiyang12,Chen Jianfeng2,Sun Bing2,Qin Jun6ORCID,Zhai Qiwei6,Li Jinsong2ORCID,Wei Bin578ORCID,Wang Jianwei4ORCID,Wang Hongyan129ORCID

Affiliation:

1. School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

2. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

3. School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

4. National Health Commission of the People’s Republic of China, Key Laboratory of System Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

5. State Key Laboratory of Virology, Wuhan Institute of Virology, Wuhan, China.

6. CAS Key Laboratory of Nutrition, Metabolism and Food Safety, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

7. College of Life Sciences, Shanghai University, Shanghai 200444, China.

8. Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China.

9. Bio-Research Innovation Center Suzhou, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Suzhou, Jiangsu 215121, China.

Abstract

Inhibition of LPA1/ROCK enhances IFN-I/III production in multiple cell types against virus infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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