Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques-Reference-Cited by-同舟云学术

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

Published:2023-06-30 Issue:26 Volume:9 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Jaeger Anna S.¹^ORCID,Crooks Chelsea M.²^ORCID,Weiler Andrea M.³^ORCID,Bliss Mason I.²,Rybarczyk Sierra³^ORCID,Richardson Alex³,Einwalter Morgan³^ORCID,Peterson Eric³^ORCID,Capuano Saverio³,Barkhymer Alison⁴,Becker Jordan T.⁵^ORCID,Greene Joseph T.⁶^ORCID,Freedman Tanya S.⁶⁷⁸^ORCID,Langlois Ryan A.⁴^ORCID,Friedrich Thomas C.²³^ORCID,Aliota Matthew T.¹^ORCID

Affiliation:

1. Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, Saint Paul, Minnesota, USA.

2. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

3. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.

4. Department of Microbiology and Immunology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

5. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

6. Department of Pharmacology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

7. Center for Immunology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

8. Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

Abstract

Spondweni virus (SPONV) is the closest known relative of Zika virus (ZIKV). SPONV pathogenesis resembles that of ZIKV in pregnant mice, and both viruses are transmitted by Aedes aegypti mosquitoes. We aimed to develop a translational model to further understand SPONV transmission and pathogenesis. We found that cynomolgus macaques ( Macaca fascicularis ) inoculated with ZIKV or SPONV were susceptible to ZIKV but resistant to SPONV infection. In contrast, rhesus macaques ( Macaca mulatta ) supported productive infection with both ZIKV and SPONV and developed robust neutralizing antibody responses. Crossover serial challenge in rhesus macaques revealed that SPONV immunity did not protect against ZIKV infection, whereas ZIKV immunity was fully protective against SPONV infection. These findings establish a viable model for future investigation into SPONV pathogenesis and suggest that the risk of SPONV emergence is low in areas with high ZIKV seroprevalence due to one-way cross-protection between ZIKV and SPONV.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adg3444

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