A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function

Author:

Xiao Mei-Fang1ORCID,Roh Seung-Eon1ORCID,Zhou Jiechao1ORCID,Chien Chun-Che1ORCID,Lucey Brendan P.2ORCID,Craig Michael T.3ORCID,Hayes Lindsay N.1ORCID,Coughlin Jennifer M.4ORCID,Leweke F. Markus56ORCID,Jia Min1ORCID,Xu Desheng1ORCID,Zhou Weiqiang7ORCID,Conover Talbot C.8ORCID,Arnold Don B.9ORCID,Staley Melissa4ORCID,Jiang Cindy4ORCID,Reti Irving M.4ORCID,Sawa Akira141011ORCID,Pelkey Kenneth A.12ORCID,McBain Chris J.12ORCID,Savonenko Alena13ORCID,Worley Paul F.114ORCID

Affiliation:

1. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

2. Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

3. Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, UK.

4. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

5. Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

6. Youth Mental Health Team, Brain and Mind Centre, Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

7. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

8. Transcriptomics and Deep Sequencing Core Facility, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

9. Department of Biology, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA.

10. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

11. Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

12. Program in Developmental Neurobiology, Eunice Kennedy-Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

13. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

14. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

CSF NPTX2 is a biomarker of schizophrenia and supports a model that integrates across genetics, pharmacology, and behavior.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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