Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates-Reference-Cited by-同舟云学术

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

Published:2021-10-22 Issue:43 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Brelstaff Jack H.¹^ORCID,Mason Matthew¹^ORCID,Katsinelos Taxiarchis¹²^ORCID,McEwan William A.¹²^ORCID,Ghetti Bernardino³,Tolkovsky Aviva M.¹^ORCID,Spillantini Maria Grazia¹^ORCID

Affiliation:

1. Department of Clinical Neurosciences, Clifford Allbutt Building, University of Cambridge, Cambridge CB2 0AH, UK.

2. UK Dementia Research Institute Cambridge, Island Research Building, University of Cambridge, Cambridge CB2 0AH, UK.

3. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.

Abstract

Microglia change their behavior when eating live neurons containing tau protein aggregates, a hallmark of Alzheimer’s disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Tau pathology and neurodegeneration

2. Neuropathological stageing of Alzheimer-related changes

3. Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

4. Extracellular tau induces microglial phagocytosis of living neurons in cell cultures

5. Microglia mediate non‐cell‐autonomous cell death of retinal ganglion cells

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