In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI-Reference-Cited by-同舟云学术

In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI

Published:2024-07-19 Issue:29 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Wu Dan¹²³^ORCID,Lee Hong-Hsi⁴^ORCID,Ba Ruicheng¹^ORCID,Turnbill Victoria⁵^ORCID,Wang Xiaoli⁶^ORCID,Luo Yu⁷^ORCID,Walczak Piotr⁸^ORCID,Fieremans Els⁹^ORCID,Novikov Dmitry S.⁹^ORCID,Martin Lee J.¹⁰^ORCID,Northington Frances J.⁵^ORCID,Zhang Jiangyang⁹^ORCID

Affiliation:

1. Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China.

2. Department of Radiology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.

3. Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China.

4. Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

5. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

6. School of Medical Imaging, Weifang Medical School, Weifang, Shandong, China.

7. Department of Radiology, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China.

8. Department of Radiology, University of Maryland, Baltimore, MD, USA.

9. Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA.

10. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Noninvasive mapping of cellular pathology can provide critical diagnostic and prognostic information. Recent advances in diffusion magnetic resonance imaging enabled in vivo examination of tissue microstructures well beyond the imaging resolution. Here, we proposed to use diffusion time–dependent diffusion kurtosis imaging ( t DKI) to simultaneously assess cellular morphology and transmembrane permeability in hypoxic-ischemic (HI) brain injury. Through numerical simulations and organoid imaging, we demonstrated the feasibility of capturing effective size and permeability changes using t DKI. In vivo MRI of HI-injured mouse brains detected a shift of the t DKI peak to longer diffusion times, suggesting swelling of the cellular processes. Furthermore, we observed a faster decrease of the t DKI tail, reflecting increased transmembrane permeability associated with up-regulated water exchange or necrosis. Such information, unavailable from a single diffusion time, can predict salvageable tissues. Preliminary applications of t DKI in patients with ischemic stroke suggested increased transmembrane permeability in stroke regions, illustrating t DKI’s potential for detecting pathological changes in the clinics.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adk1817

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