Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques

Author:

Bewley Kevin R.1ORCID,Gooch Karen1,Thomas Kelly M.1ORCID,Longet Stephanie1,Wiblin Nathan1,Hunter Laura1,Chan Kin1,Brown Phillip1ORCID,Russell Rebecca A.2ORCID,Ho Catherine1,Slack Gillian1,Humphries Holly E.1ORCID,Alden Leonie1,Allen Lauren1ORCID,Aram Marilyn1ORCID,Baker Natalie1,Brunt Emily1,Cobb Rebecca1,Fotheringham Susan1,Harris Debbie1,Kennard Chelsea1,Leung Stephanie1ORCID,Ryan Kathryn1ORCID,Tolley Howard1,Wand Nadina1,White Andrew1ORCID,Sibley Laura1ORCID,Sarfas Charlotte1ORCID,Pearson Geoff1,Rayner Emma1,Xue Xiaochao2,Lambe Teresa3ORCID,Charlton Sue1,Gilbert Sarah3ORCID,Sattentau Quentin J.2ORCID,Gleeson Fergus4,Hall Yper1ORCID,Funnell Simon15,Sharpe Sally1,Salguero Francisco J.1,Gorringe Andrew1ORCID,Carroll Miles16ORCID

Affiliation:

1. Public Health England, Porton Down, Salisbury SP4 0JG, UK.

2. The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

3. The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.

4. Oxford Departments of Radiology and Nuclear Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK.

5. Quadram Institute Bioscience, Norwich Research Park, Norfolk, UK.

6. Pandemic Preparedness Centre, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7LG, UK.

Abstract

No evidence of vaccine-enhanced disease was observed following inactivated SARS-CoV-2 vaccine in ferrets or rhesus macaques.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Coronovirus Disease (2019) Weekly Epidemiological Update; www.who.int/docs/default-source/coronaviruse/situation-reports/20200824-weekly-epi-update.pdf?sfvrsn=806986d1_4.

2. Developing Covid-19 Vaccines at Pandemic Speed

3. Status Report on COVID-19 Vaccines Development

4. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

5. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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