Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

Author:

Kespohl Meike12ORCID,Bredow Clara1,Klingel Karin3,Voß Martin1,Paeschke Anna1,Zickler Martin1,Poller Wolfgang4,Kaya Ziya56,Eckstein Johannes1,Fechner Henry7,Spranger Joachim8,Fähling Michael9ORCID,Wirth Eva Katrin8ORCID,Radoshevich Lilliana10ORCID,Thery Fabien1112ORCID,Impens Francis111213ORCID,Berndt Nikolaus114ORCID,Knobeloch Klaus-Peter15ORCID,Beling Antje12ORCID

Affiliation:

1. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Berlin, Germany.

2. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Berlin, Germany.

3. University of Tuebingen, Cardiopathology, Institute for Pathology and Neuropathology, Tuebingen, Germany.

4. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Clinic for Cardiology, Campus Benjamin Franklin, Berlin, Germany.

5. Universitätsklinikum Heidelberg, Medizinische Klinik für Innere Medizin III: Kardiologie, Angiologie und Pneumologie, Heidelberg, Germany.

6. Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Heidelberg, Germany.

7. Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.

8. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany.

9. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Vegetative Physiology, Berlin, Germany.

10. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.

11. Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

12. VIB Center for Medical Biotechnology, Ghent, Belgium.

13. VIB Proteomics Core, Ghent, Belgium.

14. Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Berlin, Germany.

15. University of Freiburg, Institute of Neuropathology, Freiburg, Germany.

Abstract

Protein modification with ISG15 acts cooperatively with IFIT proteins and preserves glucose homeostasis.

Funder

German Research Foundation

Research Foundation Flanders

Federal ministry for education Germany

Foundation for Experimental Biomedicine Zurich, Switzerland

International Max Planck Research School for Infection Biology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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