The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions

Author:

Seitz Carina1ORCID,Huang Juan12,Geiselhöringer Anna-Lena1,Galbani-Bianchi Pamela3,Michalek Svenja1ORCID,Phan Truong San1ORCID,Reinhold Cindy1,Dietrich Lea1,Schmidt Christian1ORCID,Corazza Nadia3,Delgado M. Eugenia1,Schnalzger Theresa1,Schoonjans Kristina4ORCID,Brunner Thomas1ORCID

Affiliation:

1. Division of Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.

2. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Sichuan, P.R. China.

3. Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.

4. Laboratory of Metabolic Signaling, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Abstract

The nuclear receptor LRH-1 regulates T cell proliferation and is required for induction of T cell–regulated immune responses.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

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3. The nutrition-gut microbiome-physiology axis and allergic diseases;McKenzie C.;Immunol. Rev.,2017

4. Long chain fatty acids and gene expression in inflammation and immunity;Calder P. C.;Curr. Opin. Clin. Nutr. Metab. Care,2013

5. Phospholipid regulation of the nuclear receptor superfamily;Crowder M. K.;Adv. Biol. Regul.,2017

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