Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN-Reference-Cited by-同舟云学术

Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN

Published:2022-11-25 Issue:47 Volume:8 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yu Jingyou¹^ORCID,Thomas Paul V.²³^ORCID,McMahan Katherine¹^ORCID,Jacob-Dolan Catherine¹⁴⁵^ORCID,Liu Jinyan¹^ORCID,He Xuan¹^ORCID,Hope David¹^ORCID,Martinez Elizabeth J.²³^ORCID,Chen Wei-Hung²³,Sciacca Michaela¹,Hachmann Nicole P.¹^ORCID,Lifton Michelle¹^ORCID,Miller Jessica¹^ORCID,Powers Olivia C.¹,Hall Kevin¹,Wu Cindy¹^ORCID,Barrett Julia¹^ORCID,Swafford Isabella²³^ORCID,Currier Jeffrey R.²³^ORCID,King Jocelyn⁶^ORCID,Corbitt Courtney²³,Chang William C.²^ORCID,Golub Emily²³^ORCID,Rees Phyllis A.²³^ORCID,Peterson Caroline E.²³^ORCID,Hajduczki Agnes²³,Hussin Elizabeth³⁷,Lange Camille³⁷^ORCID,Gong Hua³⁷,Matyas Gary R.⁷^ORCID,Rao Mangala⁷^ORCID,Paquin-Proulx Dominic²³^ORCID,Gromowski Gregory D.⁶^ORCID,Lewis Mark G.⁸^ORCID,Andersen Hanne⁸^ORCID,Davis-Gardner Meredith⁹^ORCID,Suthar Mehul S.⁹^ORCID,Michael Nelson L.¹⁰^ORCID,Bolton Diane L.²³^ORCID,Joyce M. Gordon²³^ORCID,Modjarrad Kayvon²^ORCID,Barouch Dan H.¹⁴⁵^ORCID

Affiliation:

1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

2. Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.

3. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

4. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02215, USA.

5. Harvard Medical School, Boston, MA 02215, USA.

6. Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

7. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

8. Bioqual, Rockville, MD 20852, USA.

9. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA.

10. Center for Infectious Diseases Research, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.

Abstract

Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and waning immunity call for next-generation vaccine strategies. Here, we assessed the immunogenicity and protective efficacy of two SARS-CoV-2 vaccines targeting the WA1/2020 spike protein, Ad26.COV2.S (Ad26) and Spike ferritin Nanoparticle (SpFN), in nonhuman primates, delivered as either a homologous (SpFN/SpFN and Ad26/Ad26) or heterologous (Ad26/SpFN) prime-boost regimen. The Ad26/SpFN regimen elicited the highest CD4 T cell and memory B cell responses, the SpFN/SpFN regimen generated the highest binding and neutralizing antibody responses, and the Ad26/Ad26 regimen generated the most robust CD8 T cell responses. Despite these differences, protective efficacy against SARS-CoV-2 Omicron BA.1 challenge was similar for all three regimens. After challenge, all vaccinated monkeys showed significantly reduced peak and day 4 viral loads in both bronchoalveolar lavage and nasal swabs as compared with sham animals. The efficacy conferred by these three immunologically distinct vaccine regimens suggests that both humoral and cellular immunity contribute to protection against SARS-CoV-2 Omicron challenge.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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