METTL6 is a tRNA m 3 C methyltransferase that regulates pluripotency and tumor cell growth-Reference-Cited by-同舟云学术

METTL6 is a tRNA m 3 C methyltransferase that regulates pluripotency and tumor cell growth

Published:2020-08-28 Issue:35 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Ignatova Valentina V.¹^ORCID,Kaiser Steffen²,Ho Jessica Sook Yuin³⁴^ORCID,Bing Xinyang⁵,Stolz Paul⁶^ORCID,Tan Ying Xim³,Lee Chee Leng³^ORCID,Gay Florence Pik Hoon³^ORCID,Lastres Palma Rico¹,Gerlini Raffaele⁷⁸,Rathkolb Birgit⁷⁸⁹,Aguilar-Pimentel Antonio⁷^ORCID,Sanz-Moreno Adrián⁷,Klein-Rodewald Tanja⁷^ORCID,Calzada-Wack Julia⁷,Ibragimov Emil¹,Valenta Magdalena¹^ORCID,Lukauskas Saulius¹^ORCID,Pavesi Andrea³^ORCID,Marschall Susan⁷,Leuchtenberger Stefanie⁷,Fuchs Helmut⁷,Gailus-Durner Valerie⁷^ORCID,de Angelis Martin Hrabe⁷⁸¹⁰^ORCID,Bultmann Sebastian⁶^ORCID,Rando Oliver J.⁵^ORCID,Guccione Ernesto³¹¹^ORCID,Kellner Stefanie M.²^ORCID,Schneider Robert¹⁸¹²^ORCID

Affiliation:

1. Institute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

2. Chemical Faculty, Ludwig-Maximilians Universität München, Munich, Germany.

3. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

5. University of Massachusetts Medical School, Worcester, MA 01605, USA.

6. Department of Biology II, Human Biology and BioImaging, Ludwig-Maximilians Universität München, Munich, Germany.

7. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

8. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.

9. Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University München, Munich, Germany.

10. Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, 85354 Freising, Germany.

11. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

12. Faculty of Biology, Ludwig-Maximilians Universität München, Munich, Germany.

Abstract

RNA methyltransferase METTL6 is implicated in tumor cell growth and in mouse energy consumption.

Funder

National Institute of Child Health and Human Development

Deutsche Forschungsgemeinschaft

EpiTrio consortium

AmPro program

Helmholtz Gesellschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject