Accelerated evolution of a minimal 63–amino acid dual transcription factor-Reference-Cited by-同舟云学术

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Accelerated evolution of a minimal 63–amino acid dual transcription factor

Published:2020-06-12 Issue:24 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Brödel Andreas K.¹^ORCID,Rodrigues Rui²^ORCID,Jaramillo Alfonso²³⁴^ORCID,Isalan Mark¹^ORCID

Affiliation:

1. Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.

2. Warwick Integrative Synthetic Biology Centre and School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.

3. CNRS-UMR8030, Laboratoire iSSB and Université Paris-Saclay and Université d’Évry and CEA, DRF, IG, Genoscope, Évry 91000, France.

4. Institute for Integrative Systems Biology (I2SysBio), University of Valencia-CSIC, 46980 Paterna, Spain.

Abstract

The smallest gene activator-repressor with polymerase recruitment is engineered using a 63–amino acid peptide.

Funder

European Commission

BBSRC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

1. Evolution of transcription factors and the gene regulatory network in Escherichia coli

2. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea

3. The evolution of genetic regulatory systems in bacteria

4. Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation

5. Activating Transcription in Bacteria

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