Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

Author:

Heden Timothy D.123ORCID,Johnson Jordan M.12456ORCID,Ferrara Patrick J.12456,Eshima Hiroaki4ORCID,Verkerke Anthony R. P.12456,Wentzler Edward J.12ORCID,Siripoksup Piyarat46ORCID,Narowski Tara M.12,Coleman Chanel B.12ORCID,Lin Chien-Te17,Ryan Terence E.178ORCID,Reidy Paul T.46ORCID,de Castro Brás Lisandra E.7,Karner Courtney M.9ORCID,Burant Charles F.10,Maschek J. Alan11ORCID,Cox James E.41112ORCID,Mashek Douglas G.3ORCID,Kardon Gabrielle13ORCID,Boudina Sihem4514ORCID,Zeczycki Tonya N.115ORCID,Rutter Jared412ORCID,Shaikh Saame Raza11516,Vance Jean E.17,Drummond Micah J.45614,Neufer P. Darrell127ORCID,Funai Katsuhiko12456ORCID

Affiliation:

1. East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA.

2. Department of Kinesiology, East Carolina University, Greenville, NC, USA.

3. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.

4. Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA.

5. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.

6. Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, USA.

7. Department of Physiology, East Carolina University, Greenville, NC, USA.

8. Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.

9. Department of Orthopedic Surgery & Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA.

10. Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI, USA.

11. Metabolomics Core Research Facility, University of Utah, Salt Lake City, UT, USA.

12. Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.

13. Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.

14. Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.

15. Department of Biochemistry and Molecular Biology, East Carolina University, Greenville, NC, USA.

16. Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.

17. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Abstract

Mitochondrial membrane lipids adapt to exercise or disuse, underscoring an essential role for PE in energy transduction.

Funder

National Institute on Aging

National Heart, Lung, and Blood Institute

NIH Office of the Director

National Institute of Diabetes and Digestive and Kidney Diseases

American Heart Association

Larry H. & Gail Miller Foundation

National Center for Complementary and Integrative Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference51 articles.

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2. Limiting factors for maximum oxygen uptake and determinants of endurance performance;Bassett D. R.;Med. Sci. Sports Exerc.,2000

3. Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle;Holloszy J. O.;J. Biol. Chem.,1967

4. Time course of changes in human skeletal muscle succinate dehydrogenase and cytochrome oxidase activities and maximal oxygen uptake with physical activity and inactivity;Henriksson J.;Acta Physiol. Scand.,1977

5. Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

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