Identification of variable lymphocyte receptors that can target therapeutics to pathologically exposed brain extracellular matrix

Author:

Umlauf Benjamin J.1ORCID,Clark Paul A.2ORCID,Lajoie Jason M.1,Georgieva Julia V.1,Bremner Samantha1ORCID,Herrin Brantley R.3ORCID,Kuo John S.2456ORCID,Shusta Eric V.14ORCID

Affiliation:

1. Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.

2. Department of Neurological Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.

3. Emory University, Atlanta, GA, USA.

4. Carbone Cancer Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.

5. Department of Neurosurgery, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.

6. Mulva Clinic for the Neurosciences, The University of Texas at Austin, Austin, TX, USA.

Abstract

This study demonstrates targeting of blood-brain barrier disruption to deliver payloads at sites of neurological disease.

Funder

National Institutes of Health

Defense Threat Reduction Agency

Dr. Ralph and Marian Falk Medical Research Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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