GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells-Reference-Cited by-同舟云学术

GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells

Published:2021-03-12 Issue:11 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

El K.¹^ORCID,Gray S. M.¹^ORCID,Capozzi M. E.¹^ORCID,Knuth E. R.²,Jin E.²,Svendsen B.¹,Clifford A.¹,Brown J. L.¹^ORCID,Encisco S. E.¹^ORCID,Chazotte B. M.¹,Sloop K. W.³^ORCID,Nunez D. J.¹^ORCID,Merrins M. J.²^ORCID,D’Alessio D. A.¹⁴^ORCID,Campbell J. E.¹⁴⁵^ORCID

Affiliation:

1. Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.

2. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

3. Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.

4. Division of Endocrinology, Department of Medicine, Duke University, Durham, NC, USA.

5. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.

Abstract

GIPR activity in α cells is required for the complete metabolic response to a meal.

Funder

National Institutes of Health

American Diabetes Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

2. The incretin system in healthy humans: The role of GIP and GLP-1

3. Advances in oral peptide therapeutics

4. Is GLP ‐1 a hormone: Whether and When?

5. Incretin Secretion in Relation to Meal Size and Body Weight in Healthy Subjects and People with Type 1 and Type 2 Diabetes Mellitus

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