Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation-Reference-Cited by-同舟云学术

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Published:2020-05-22 Issue:21 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Guerra J.¹^ORCID,Valadao A.-L.¹,Vlachakis D.²^ORCID,Polak K.¹,Vila I. K.¹^ORCID,Taffoni C.¹^ORCID,Prabakaran T.³,Marriott A. S.⁴,Kaczmarek R.⁵^ORCID,Houel A.⁶^ORCID,Auzemery B.¹^ORCID,Déjardin S.¹^ORCID,Boudinot P.⁶^ORCID,Nawrot B.⁵^ORCID,Jones N. J.⁷^ORCID,Paludan S. R.³^ORCID,Kossida S.⁸,Langevin C.⁶^ORCID,Laguette N.¹^ORCID

Affiliation:

1. Institut de Génétique Humaine, CNRS, Université de Montpellier, Molecular Basis of Inflammation Laboratory, Montpellier, France.

2. Laboratory of Genetics, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, Greece.

3. Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

4. Department of Biology, Edge Hill University, Ormskirk, L39 4QP, UK.

5. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland.

6. Université Paris-Saclay, INRAE, UVSQ, VIM, 78350 Jouy-en-Josas, France.

7. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.

8. Institut de Génétique Humaine, CNRS, Université de Montpellier, IMGT, the International ImMunoGeneTics Information System, Montpellier, France.

Abstract

The LysRS-Ap 4 A axis impairs cGAS-STING pathway activation, delaying nucleic acid-driven innate immune responses.

Funder

Cancer Research UK

European Research Council

Agence Nationale de la Recherche