Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium-Reference-Cited by-同舟云学术

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

Published:2020-10-02 Issue:40 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mizukoshi Yumiko¹,Takeuchi Koh²^ORCID,Tokunaga Yuji²^ORCID,Matsuo Hitomi¹,Imai Misaki¹,Fujisaki Miwa¹,Kamoshida Hajime¹,Takizawa Takeshi³,Hanzawa Hiroyuki³,Shimada Ichio⁴⁵^ORCID

Affiliation:

1. Japan Biological Informatics Consortium, Tokyo 135-0063, Japan.

2. National Institute of Advanced Industrial Science and Technology (AIST), Molecular Profiling Research Center for Drug Discovery (molprof) and Cellular and Molecular Biotechnology Research Institute, Tokyo 135-0063, Japan.

3. Daiichi Sankyo RD Novare Co. Ltd., Tokyo 134-8630, Japan.

4. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

5. RIKEN, Center for Biosystems Dynamics Research, Yokohama 230-0045, Japan.

Abstract

An NMR-based strategy was established to improve protein druggability by stabilizing cryptic binding sites in an equilibrium.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary