Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts

Author:

Yang Sujuan12ORCID,Zhang Ximei13ORCID,Chen Jingrong1,Dang Junlong12,Liang Rongzhen1,Zeng Donglan1,Zhang Huan1,Xue Youqiu3,Liu Yan1ORCID,Wu Wenbin1,Zhao Jun1ORCID,Wang Julie3,Pan Yunfeng1,Xu Hanshi4,Sun Bing5,Huang Feng1,Lu Yan1ORCID,Hsueh Willa3,Olsen Nancy2ORCID,Zheng Song Guo3ORCID

Affiliation:

1. Department of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

2. Department of Medicine, The Penn State University Hershey Medical Center, Hershey, PA 17033, USA.

3. Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

4. Department of Internal Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

5. Department of Immunology, Institute of Biochemistry at Chinese Academy of Science, Shanghai 200031, China.

Abstract

Induced regulatory T cells are phenotypic and functionally stable when encountering inflamed synovial fibroblast.

Funder

National Institutes of Health

China National Natural Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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