HSPA13 facilitates NF-κB–mediated transcription and attenuates cell death responses in TNFα signaling

Author:

Gao Chun123ORCID,Deng Jianhua123,Zhang Hanchenxi123,Li Xinran123ORCID,Gu Shuchen123ORCID,Zheng Mingjie4ORCID,Tang Mei1ORCID,Zhu Yezhang1,Lin Xin5ORCID,Jin Jianping1ORCID,Zhang Long123ORCID,Huang Jun123,Zou Jian4ORCID,Xia Zong-Ping16ORCID,Xu Ping-Long123ORCID,Shen Li1ORCID,Zhao Bin123ORCID,Feng Xin-Hua1237ORCID

Affiliation:

1. The MOE Key Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

2. Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

3. Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China.

4. Eye Center of the Second Affiliated Hospital School of Medicine, Institutes of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.

5. Institute for Immunology, Tsinghua University School of Medicine, Tsinghua University–Peking University Jointed Center for Life Sciences, Beijing 100084, China.

6. The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.

7. The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Abstract

HSPA13 is a novel checkpoint regulator in the TNFα signaling pathway controlling cellular physiological outcomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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