Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

Author:

Murphy Kendelle J.12ORCID,Reed Daniel A.12ORCID,Vennin Claire123,Conway James R. W.124ORCID,Nobis Max12ORCID,Yin Julia X.12ORCID,Chambers Cecilia R.12ORCID,Pereira Brooke A.12ORCID,Lee Victoria1ORCID,Filipe Elysse C.12ORCID,Trpceski Michael1,Ritchie Shona12ORCID,Lucas Morghan C.12ORCID,Warren Sean C.12ORCID,Skhinas Joanna N.1,Magenau Astrid12,Metcalf Xanthe L.1ORCID,Stoehr Janett1ORCID,Major Gretel1ORCID,Parkin Ashleigh12,Bidanel Romain1,Lyons Ruth J.1,Zaratzian Anaiis1,Tayao Michael1ORCID,Da Silva Andrew1,Abdulkhalek Lea1,Gill Anthony J.12567ORCID,Johns Amber L.1,Biankin Andrew V.89ORCID,Samra Jaswinder10,Grimmond Sean M.11ORCID,Chou Angela156712ORCID,Goetz Jacky G.131415ORCID,Samuel Michael S.1617ORCID,Lyons J. Guy181920ORCID,Burgess Andrew2122ORCID,Caldon C. Elizabeth12ORCID,Horvath Lisa G.12523,Daly Roger J.24ORCID,Gadegaard Nikolaj25ORCID,Wang Yingxiao26ORCID,Sansom Owen J.827ORCID,Morton Jennifer P.827ORCID,Cox Thomas R.12ORCID,Pajic Marina12ORCID,Herrmann David12ORCID,Timpson Paul12ORCID, ,

Affiliation:

1. Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, Sydney, NSW 2010, Australia.

2. St. Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.

3. Oncode Institute, Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.

4. Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.

5. Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.

6. NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, NSW 2065, Australia.

7. Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, NSW 2064, Australia.

8. Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

9. West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.

10. Department of Surgery, Royal North Shore Hospital, Sydney, NSW 2065, Australia.

11. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia.

12. Department of Anatomical Pathology, SydPath, Darlinghurst, NSW 2010, Australia.

13. INSERM UMR, Tumour Biomechanics, Strasbourg, France.

14. Université de Strasbourg, Strasbourg, France.

15. Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.

16. Centre for Cancer Biology, SA Pathology and University of South Australia, SA, Australia.

17. Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.

18. Dermatology, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia.

19. Cancer Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

20. Centenary Institute, The University of Sydney, Camperdown, NSW, Australia.

21. ANZAC Research Institute, Sydney, NSW 2139, Australia.

22. Faculty of Medicine and Health, Concord Clinical School, University of Sydney, Sydney, NSW 2000, Australia.

23. Medical Oncology, Chris O’Brien Lifehouse, Camperdown, NSW 2006, Australia.

24. Cancer Program and Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

25. James Watt School of Engineering, University of Glasgow, Glasgow, UK.

26. Department of Bioengineering and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.

27. Cancer Research UK Beatson Institute, Glasgow, UK.

Abstract

Intravital imaging guides a personalized medicine approach to target mechanoreciprocity in pancreatic cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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