Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

Author:

Bierbrauer Anne1ORCID,Kunz Lukas234ORCID,Gomes Carlos A.1,Luhmann Maike5ORCID,Deuker Lorena1,Getzmann Stephan6,Wascher Edmund6,Gajewski Patrick D.6,Hengstler Jan G.6,Fernandez-Alvarez Marina7ORCID,Atienza Mercedes7,Cammisuli Davide M.8,Bonatti Francesco9,Pruneti Carlo8ORCID,Percesepe Antonio9ORCID,Bellaali Youssef10,Hanseeuw Bernard1011,Strange Bryan A.1213ORCID,Cantero Jose L.7,Axmacher Nikolai114ORCID

Affiliation:

1. Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

2. Epilepsy Center, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany.

3. Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.

4. Faculty of Biology, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.

5. Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.

6. Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

7. Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.

8. Department of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy.

9. Department of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy.

10. Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.

11. Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

12. Department of Neuroimaging, Alzheimer’s Disease Research Centre, Reina Sofia–CIEN Foundation, Madrid, Spain.

13. Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid, Madrid, Spain.

14. State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.

Abstract

Alzheimer’s risk carriers exhibit impaired path integration performance when compensatory strategies cannot be used.

Funder

NIH Office of the Director

NSF Office of the Director

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Spanish Ministry of Economy and Competitiveness

International Center on Aging CENIE-POCTEP

Regional Ministry of Innovation, Science and Enterprise, Junta de Andalucia

CIBERNED

Emma and Ernesto Rulfo Foundation for Medical Genetics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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