Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma

Author:

Zimmerman Mark W.1ORCID,Durbin Adam D.12ORCID,He Shuning1ORCID,Oppel Felix1ORCID,Shi Hui13ORCID,Tao Ting145ORCID,Li Zhaodong1ORCID,Berezovskaya Alla1,Liu Yu6,Zhang Jinghui6ORCID,Young Richard A.78ORCID,Abraham Brian J.6ORCID,Look A. Thomas1ORCID

Affiliation:

1. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

2. Division of Molecular Oncology, Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

3. College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310052, China.

4. National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310052, China.

5. Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, China.

6. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

7. Whitehead Institute, Cambridge, MA 02142, USA.

8. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

Retinoic acid reprograms neuroblastoma cell identity by remodeling the core transcriptional regulatory circuitry.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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