Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation-Reference-Cited by-同舟云学术

Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation

Published:2021-11-26 Issue:65 Volume:6 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Kurgyis Zsuzsanna¹²³^ORCID,Vornholz Larsen¹²,Pechloff Konstanze¹²,Kemény Lajos V.⁴⁵^ORCID,Wartewig Tim¹²^ORCID,Muschaweckh Andreas⁶^ORCID,Joshi Abhinav¹²^ORCID,Kranen Katja³,Hartjes Lara¹²,Möckel Sigrid³⁷,Steiger Katja⁸^ORCID,Hameister Erik¹²,Volz Thomas³^ORCID,Mellett Mark⁹^ORCID,French Lars E.⁹¹⁰¹¹^ORCID,Biedermann Tilo³^ORCID,Korn Thomas⁶¹²¹³^ORCID,Ruland Jürgen¹²¹⁴¹⁵^ORCID

Affiliation:

1. Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.

2. TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany.

3. Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany.

4. Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

5. Department of Dermatology, Venereology, and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

6. Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

7. Institute of Pathology, Universität Würzburg, Würzburg, Germany.

8. Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.

9. Department of Dermatology, University Hospital of Zürich, University of Zurich (UZH), Zürich, Switzerland.

10. Department of Dermatology and Allergy, University Hospital, LMU Munich Munich, Germany.

11. Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

12. Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich Germany.

13. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

14. German Cancer Consortium (DKTK), Heidelberg, Germany.

15. German Center for Infection Research (DZIF), Munich partner site, Munich Germany.

Abstract

BCL10/MALT1 signaling in keratinocytes is altered in human sporadic psoriasis and is a critical initiator and amplifier of skin inflammation in mouse models.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference73 articles.

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4. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

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