GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment-Reference-Cited by-同舟云学术

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

Published:2019-12-06 Issue:42 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Halaby Marie Jo¹²^ORCID,Hezaveh Kebria¹²^ORCID,Lamorte Sara¹²,Ciudad M. Teresa¹²,Kloetgen Andreas³,MacLeod Bethany L.¹²,Guo Mengdi¹²,Chakravarthy Ankur⁴^ORCID,Medina Tiago Da Silva⁵^ORCID,Ugel Stefano⁶^ORCID,Tsirigos Aristotelis³⁷⁸^ORCID,Bronte Vincenzo⁶^ORCID,Munn David H.⁹¹⁰^ORCID,Pugh Trevor J.¹⁴¹¹^ORCID,De Carvalho Daniel D.¹⁴^ORCID,Butler Marcus O.¹^ORCID,Ohashi Pamela S.¹²⁴,Brooks David G.¹²,McGaha Tracy L.¹²^ORCID

Affiliation:

1. Tumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

2. Department of Immunology, University of Toronto, Toronto, ON, Canada.

3. Department of Pathology, New York University School of Medicine, New York, NY, USA.

4. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

5. A.C. Camargo Cancer Center, Sao Paulo, Brazil.

6. Department of Medicine, Immunology Section, Verona University Hospital, Verona, Italy.

7. Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.

8. Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY, USA.

9. Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA.

10. Georgia Cancer Center, Augusta, GA, USA.

11. Ontario Institute for Cancer Research, Toronto, ON, Canada.

Abstract

GCN2 is a key driver of Mϕ and MDSC polarization in the tumor microenvironment causing T cell exhaustion.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Canadian Institutes of Health Research

Canada First Research Excellence Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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