The human thymus perivascular space is a functional niche for viral-specific plasma cells-Reference-Cited by-同舟云学术

The human thymus perivascular space is a functional niche for viral-specific plasma cells

Published:2016-12-23 Issue:6 Volume:1 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Nuñez Sarah¹²,Moore Carolina³,Gao Baoshan³,Rogers Kortney¹,Hidalgo Yessia²,del Nido Pedro J.⁴,Restaino Susan⁵,Naka Yoshifumi⁶,Bhagat Govind⁷,Madsen Joren C.³,Bono María Rosa²,Zorn Emmanuel¹

Affiliation:

1. Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

2. Department of Biology, University of Chile, Santiago, Chile.

3. MGH Transplant Center and Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

4. Department of Surgery, Boston Children’s Hospital, Boston, MA 02115, USA.

5. Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.

6. Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.

7. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

Abstract

The human thymus perivascular space houses viral-specific plasma cells and memory B cells producing protective antibodies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference46 articles.

1. The Thymus Is a Common Target Organ in Infectious Diseases

2. Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development

3. Tolerance has its limits: how the thymus copes with infection

4. T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells.

5. Neonatal exposure to thymotropic gross murine leukemia virus induces virus-specific immunologic nonresponsiveness.

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