KIR3DS1 directs NK cell–mediated protection against human adenovirus infections

Author:

Jung Johannes M.12ORCID,Ching Wilhelm2,Baumdick Martin E.1ORCID,Hofmann-Sieber Helga2,Bosse Jens B.3456ORCID,Koyro Tobias17ORCID,Möller Kimberly J.1ORCID,Wegner Lucy1ORCID,Niehrs Annika1ORCID,Russu Kristina1ORCID,Ohms Mareike1,Zhang Wenli8,Ehrhardt Anja8,Duisters Kevin9ORCID,Spierings Eric10ORCID,Hölzemer Angelique11112,Körner Christian1ORCID,Jansen Suze A.131415ORCID,Peine Sven16,Königs Ingo17ORCID,Lütgehetmann Marc18ORCID,Perez Daniel19,Reinshagen Konrad20,Lindemans Caroline A.131415ORCID,Altfeld Marcus1,Belderbos Mirjam14ORCID,Dobner Thomas2ORCID,Bunders Madeleine J.17

Affiliation:

1. Research Department Virus Immunology, Leibniz Institute for Experimental Virology, Hamburg, Germany.

2. Research Department Viral Transformation, Leibniz Institute for Experimental Virology, Hamburg, Germany.

3. Leibniz Institute for Experimental Virology, Hamburg, Germany.

4. Centre for Structural Systems Biology, Hamburg, Germany.

5. Hannover Medical School, Institute of Virology, Hannover, Germany.

6. Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.

7. III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

8. Faculty of Health, Centre for Biomedical Education and Research (ZBAF), School of Human Medicine, Institute of Virology and Microbiology, Witten/Herdecke University, Witten, Germany.

9. Mathematical Institute, Leiden University, Leiden, Netherlands.

10. Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

11. I. Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Eppendorf, Hamburg, Germany.

12. German Center for Infection Research (DZIF), Site Hamburg-Lübeck-Borstel-Riems, Germany.

13. Wilhelmina Children’s Hospital/Department of Pediatrics, University Medical Center Utrecht, University Utrecht, Utrecht, Netherlands.

14. Pediatric Blood and Marrow Transplantation Program, Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.

15. Regenerative Medicine Center, University Utrecht, Utrecht, Netherlands.

16. Institute for Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

17. Department of Pediatric Surgery, Altona Children’s Hospital, Hamburg, Germany.

18. Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

19. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

20. Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Abstract

KIR3DS1 + NK cells execute enhanced killing of adenovirus-infected cells, providing protection against severe infection in immunocompromised hosts.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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