Identification of two distinct pathways of human myelopoiesis

Author:

Drissen Roy1ORCID,Thongjuea Supat23ORCID,Theilgaard-Mönch Kim45,Nerlov Claus1ORCID

Affiliation:

1. MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

2. MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

3. NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

4. Department of Hematology and Finsen Laboratory, National University Hospital, Denmark.

5. Biotech Research and Innovation Centre and Program for Translational Hematology - The Novo Nordisk Foundation Center for Stem Cell Biology, University of Copenhagen, Copenhagen, Denmark.

Abstract

Distinct myeloid differentiation pathways give rise to either neutrophil/monocyte or basophil/mast cell/eosinophil lineages.

Funder

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference39 articles.

1. The innate immune response

2. Emergency granulopoiesis

3. Molecular alterations underlying eosinophilic and mast cell malignancies;Sadrzadeh H.;Discov. Med.,2011

4. Resolution of inflammation: an integrated view

5. Coordinated regulation of myeloid cells by tumours

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