Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T reg cells by inhibition of CDK8/19-Reference-Cited by-同舟云学术

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing T reg cells by inhibition of CDK8/19

Published:2019-10-11 Issue:40 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Akamatsu Masahiko¹²^ORCID,Mikami Norihisa³⁴^ORCID,Ohkura Naganari³⁵,Kawakami Ryoji³,Kitagawa Yohko³,Sugimoto Atsushi³,Hirota Keiji⁴,Nakamura Naoto²^ORCID,Ujihara Satoru²^ORCID,Kurosaki Toshio²^ORCID,Hamaguchi Hisao²^ORCID,Harada Hironori²^ORCID,Xia Guliang⁶,Morita Yoshiaki¹²^ORCID,Aramori Ichiro¹²,Narumiya Shuh¹^ORCID,Sakaguchi Shimon³⁴^ORCID

Affiliation:

1. Center for Innovation in Immunoregulation Technology and Therapeutics, Kyoto University Graduate School of Medicine, Konoe-cho Yoshida, Sakyo-ku, Kyoto, Kyoto 606-8501, Japan.

2. Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.

3. Department of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Yamadaoka, Suita, Osaka 565-0871, Japan.

4. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Kyoto 606-8507, Japan.

5. Department of Frontier Research in Tumor Immunology, Center of Medical Innovation and Translational Research, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.

6. Astellas Research Institute of America, Skokie, IL 60077, USA.

Abstract

CDK8/19 inhibitors can convert naïve and memory/effector T cells into T reg cells capable of treating immunological diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference50 articles.

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5. Molecular mechanisms regulating TGF-β-induced Foxp3 expression;Xu L.;Mucosal Immunol.,2010

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