Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism-Reference-Cited by-同舟云学术

Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

Published:2017-02-24 Issue:8 Volume:2 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Thompson A. A. Roger¹,Dickinson Rebecca S.²,Murphy Fiona²,Thomson John P.³,Marriott Helen M.¹,Tavares Adriana⁴,Willson Joseph²,Williams Lynne¹,Lewis Amy¹,Mirchandani Ananda²,Dos Santos Coelho Patricia²,Doherty Catherine²,Ryan Eilise²,Watts Emily²,Morton Nicholas M.⁴,Forbes Shareen⁴,Stimson Roland H.⁴,Hameed Abdul G.¹,Arnold Nadine¹,Preston Julie A.¹,Lawrie Allan¹,Finisguerra Veronica⁵⁶,Mazzone Massimiliano⁵⁶,Sadiku Pranvera²,Goveia Jermaine⁷⁸,Taverna Federico⁷⁸,Carmeliet Peter⁷⁸,Foster Simon J.⁹,Chilvers Edwin R.¹⁰,Cowburn Andrew S.¹⁰¹¹,Dockrell David H.¹,Johnson Randall S.¹¹,Meehan Richard R.³,Whyte Moira K. B.²,Walmsley Sarah R.²

Affiliation:

1. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, U.K.

2. Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, U.K.

3. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.

4. University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, U.K.

5. Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven B3000, Belgium.

6. Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven B3000, Belgium.

7. Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Leuven B3000, Belgium.

8. Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, KU Leuven, Leuven B3000, Belgium.

9. Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, U.K.

10. Department of Medicine, University of Cambridge, Cambridge, U.K.

11. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, U.K.

Abstract

Infection outcomes are regulated by neutrophil responses to oxygen and nutrient availability.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference44 articles.

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3. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens;Werth N.;PLOS ONE,2010

4. The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

5. The burden of lung disease;Hubbard R.;Thorax,2006

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