The immune system profoundly restricts intratumor genetic heterogeneity-Reference-Cited by-同舟云学术

The immune system profoundly restricts intratumor genetic heterogeneity

Published:2018-11-30 Issue:29 Volume:3 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Milo Idan¹²^ORCID,Bedora-Faure Marie³,Garcia Zacarias¹²,Thibaut Ronan¹²⁴,Périé Leïla⁵⁶,Shakhar Guy⁷^ORCID,Deriano Ludovic³^ORCID,Bousso Philippe¹²^ORCID

Affiliation:

1. Dynamics of Immune Responses Unit, Equipe Labellisée Ligue Contre le Cancer, Institut Pasteur, 75015 Paris, France.

2. INSERM U1223, 75015 Paris, France.

3. Genome Integrity, Immunity and Cancer Unit, Department of Immunology, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.

4. University Paris Diderot, Sorbonne Paris Cité, Cellule Pasteur, rue du Dr Roux, 75015 Paris, France.

5. Institut Curie, PSL Research University, CNRS UMR168, 11 rue Pierre et Marie Curie, 75005 Paris, France.

6. Sorbonne Universités, UPMC University Paris 06, 4 place Jussieu, 75005 Paris, France.

7. Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Host immune responses and checkpoint inhibition reduce clonal and genetic intratumor diversity.

Funder

European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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