Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment

Author:

Heidkamp Gordon F.1,Sander Jil2,Lehmann Christian H. K.1,Heger Lukas1,Eissing Nathalie1,Baranska Anna1,Lühr Jennifer J.1,Hoffmann Alana1,Reimer Katharina C.1,Lux Anja3,Söder Stephan4,Hartmann Arndt4,Zenk Johannes5,Ulas Thomas2,McGovern Naomi6,Alexiou Christoph7,Spriewald Bernd8,Mackensen Andreas8,Schuler Gerold9,Schauf Burkhard10,Forster Anja10,Repp Roland11,Fasching Peter A.12,Purbojo Ariawan13,Cesnjevar Robert13,Ullrich Evelyn1415,Ginhoux Florent6,Schlitzer Andreas2616,Nimmerjahn Falk3,Schultze Joachim L.216,Dudziak Diana1

Affiliation:

1. Department of Dermatology, Laboratory of Dendritic Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany.

2. LIMES (Life and Medical Sciences) Institute, Genomics and Immunoregulation, University of Bonn, Bonn, Germany.

3. Department of Biology, Chair of Genetics, FAU, Erlangen, Germany.

4. Department of Pathology, FAU, University Hospital Erlangen, Erlangen, Germany.

5. Department of Otorhinolaryngology, Klinikum Augsburg Süd, Augsburg, Germany.

6. Singapore Immunology Network, A*STAR (Agency for Science Technology and Research), Singapore, Singapore.

7. Section for Experimental Oncology and Nanomedicine, Department of Otorhinolaryngology, Head and Neck Surgery, Else Kröner-Fresenius-Stiftung-Professorship, FAU, University Hospital Erlangen, Erlangen, Germany.

8. Department of Medicine 5, Hematology and Oncology, FAU, University Hospital Erlangen, Erlangen, Germany.

9. Department of Dermatology, FAU, University Hospital Erlangen, Erlangen, Germany.

10. Department of Obstetrics and Gynecology, Sozialstiftung Bamberg, Bamberg, Germany.

11. Medical Department 2, Städtisches Krankenhaus Kiel, Kiel, Germany.

12. Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, FAU, University Hospital Erlangen, Erlangen, Germany.

13. Department of Pediatric Cardiac Surgery, FAU, University Hospital Erlangen, Erlangen, Germany.

14. LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany.

15. Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents Medicine, Hospital of the Goethe University, Frankfurt, Germany.

16. Platform for Single Cell Genomics and Epigenomics (PRECISE) at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany.

Abstract

Transcriptional identity of human dendritic cell subsets is mainly dictated by ontogeny rather than by signals derived from the cells’ final tissue microenvironment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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