Identification of the miR-106b ~ 25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation-Reference-Cited by-同舟云学术

Identification of the miR-106b ~ 25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

Published:2010-04-13 Issue:117 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Poliseno Laura¹,Salmena Leonardo¹,Riccardi Luisa¹,Fornari Alessandro²³,Song Min Sup¹,Hobbs Robin M.¹,Sportoletti Paolo¹,Varmeh Shorheh¹,Egia Ainara¹,Fedele Giuseppe²⁴,Rameh Lucia⁵,Loda Massimo²⁴,Pandolfi Pier Paolo¹

Affiliation:

1. Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

3. Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, 10126 Turin, Italy.

4. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

5. Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA.

Abstract

A microRNA network regulates the tumor suppressor PTEN in prostate cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

1. Nomenclature: PTEN human protein; PTEN human mRNA and gene; Pten mouse protein; Pten mouse mRNA and gene; DICER human protein; DICER human mRNA or gene; MCM7 human protein; MCM7 human mRNA and gene; miR-X mature miRNA; miR-X miRNA gene.

2. Biogenesis of small RNAs in animals

3. Impaired microRNA processing enhances cellular transformation and tumorigenesis

4. Up-Regulation of Dicer, a Component of the MicroRNA Machinery, in Prostate Adenocarcinoma

5. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

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