Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety-Reference-Cited by-同舟云学术

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety

Published:2020-03-31 Issue:625 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Grant Benjamin M. M.¹²^ORCID,Enomoto Masahiro¹^ORCID,Back Sung-In¹²^ORCID,Lee Ki-Young¹,Gebregiworgis Teklab¹^ORCID,Ishiyama Noboru¹^ORCID,Ikura Mitsuhiko¹²^ORCID,Marshall Christopher B.¹^ORCID

Affiliation:

1. Princess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.

2. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

Abstract

Calmodulin sequesters and inhibits KRAS4b by binding a lipid-modified region of the protein.

Funder

Heart and Stroke Foundation of Canada

Princess Margaret Cancer Foundation

Canadian Cancer Society Research Institute

Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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