The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose-Reference-Cited by-同舟云学术

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

Published:2019-09-03 Issue:597 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Defenouillère Quentin¹^ORCID,Verraes Agathe¹,Laussel Clotilde¹^ORCID,Friedrich Anne²,Schacherer Joseph²,Léon Sébastien¹^ORCID

Affiliation:

1. Institut Jacques Monod, UMR 7592 Centre National de la Recherche Scientifique/Université Paris-Diderot, Sorbonne Paris Cité, 75205, Paris Cedex 13, France.

2. Université de Strasbourg, CNRS, GMGM UMR 7156, 67000 Strasbourg, France.

Abstract

An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose.

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Fondation ARC pour la Recherche sur le Cancer

Ligue Contre le Cancer - Comité de Paris

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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