Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells-Reference-Cited by-同舟云学术

Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells

Published:2020-10-13 Issue:653 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Gualdani Roberta¹^ORCID,Seghers François¹,Yerna Xavier¹,Schakman Olivier¹,Tajeddine Nicolas¹^ORCID,Achouri Younès²,Tissir Fadel³^ORCID,Devuyst Olivier⁴,Gailly Philippe¹^ORCID

Affiliation:

1. Université catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.

2. Université catholique de Louvain, de Duve Institute, Transgenic Core Facility, av. Hippocrate 75/B1.75.09, B-1200 Brussels, Belgium.

3. Université catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, av. Hippocrate 73/B1.73.16, B-1200 Brussels, Belgium.

4. University of Zurich, Institute of Physiology, Winterthurerstr. 190, CH-8057 Zurich, Switzerland.

Abstract

Fluid pressure in the proximal tubule activates TRPV4 to promote endocytosis and retention of albumin.

Funder

Swiss National Science Foundation

Fonds De La Recherche Scientifique - FNRS

French Community of Belgium

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference68 articles.

1. Receptor-mediated endocytosis in renal proximal tubule

2. Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule

3. Receptor-Mediated Endocytosis in the Proximal Tubule

4. Discerning the role of mechanosensors in regulating proximal tubule function

5. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces

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