TSLP signaling in CD4 + T cells programs a pathogenic T helper 2 cell state-Reference-Cited by-同舟云学术

TSLP signaling in CD4 + T cells programs a pathogenic T helper 2 cell state

Published:2018-03-13 Issue:521 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Rochman Yrina¹²^ORCID,Dienger-Stambaugh Krista¹^ORCID,Richgels Phoebe K.¹,Lewkowich Ian P.¹^ORCID,Kartashov Andrey V.³^ORCID,Barski Artem³⁴^ORCID,Khurana Hershey Gurjit K.⁵^ORCID,Leonard Warren J.²^ORCID,Singh Harinder¹^ORCID

Affiliation:

1. Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

2. Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.

3. Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

4. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

Abstract

The cytokine TSLP promotes the generation of a pathogenic T cell subset that exacerbates allergic responses.

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference53 articles.

1. How are TH2-type immune responses initiated and amplified?

2. History of interleukin-4

3. Sensing the outside world: TSLP regulates barrier immunity

4. TH2, allergy and group 2 innate lymphoid cells

5. Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

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