Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Na v 1.7 knockout mice-Reference-Cited by-同舟云学术

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Na v 1.7 knockout mice

Published:2017-01-10 Issue:461 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Isensee Jörg¹,Krahé Leonhardt¹,Moeller Katharina¹,Pereira Vanessa²,Sexton Jane E.²,Sun Xiaohui²,Emery Edward²,Wood John N.²,Hucho Tim¹

Affiliation:

1. Department of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany.

2. Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

The voltage-gated Na + channel Na v 1.7 controls the balance of pain-promoting and pain-relieving receptor input.

Funder

Federal Ministry of Education and Research, Germany

Bayer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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