Differential p53-Independent Outcomes of p19 Arf Loss in Oncogenesis-Reference-Cited by-同舟云学术

Differential p53-Independent Outcomes of p19 Arf Loss in Oncogenesis

Published:2009-08-18 Issue:84 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chen Zhenbang¹²,Carracedo Arkaitz¹²,Lin Hui-Kuan²,Koutcher Jason A.³,Behrendt Nille²,Egia Ainara¹²,Alimonti Andrea¹²,Carver Brett S.⁴,Gerald William²,Teruya-Feldstein Julie²,Loda Massimo⁵,Pandolfi Pier Paolo¹²

Affiliation:

1. Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, MA 02115, USA.

2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.

3. Departments of Medicine, Radiology and Medical Physics, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, New York, NY 10021, USA.

4. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

5. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

p19 Arf signals independently of p53 in prostate cancer associated with the loss of Pten.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference34 articles.

1. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2. Oncogenic Ras Induces p19ARF and Growth Arrest in Mouse Embryo Fibroblasts Lacking p21Cip1 and p27Kip1 without Activating Cyclin D-dependent Kinases

3. Antagonism of Myc functions by Arf