Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer

Author:

Chen Wei-Yu12ORCID,Tsai Yuan-Chin3,Yeh Hsiu-Lien4,Suau Florent5ORCID,Jiang Kuo-Ching3,Shao Ai-Ning3,Huang Jiaoti6,Liu Yen-Nien3ORCID

Affiliation:

1. Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.

2. Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.

3. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

4. Institute of Information System and Applications, National Tsing Hua University, Hsinchu 30013, Taiwan.

5. Department of Microbiology, Faculty of Pharmacy, Dicle University, Diyarbakir 21280, Turkey.

6. Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Loss of a TGFβ signaling repressor by androgen deprivation therapy shows how a common treatment for primary prostate cancer may promote metastasis.

Funder

Ministry of Health and Welfare

Ministry of Science and Technology, Taiwan

National Health Research Institutes

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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